The Early Person who Diagnosed with Alzheimer’s Diseases - Part 2 – Alzheimer's 2

You may read the previous post (Part 1):
- The Early Person who Diagnosed with Alzheimer’s Diseases - Part 1 – Alzheimer's 2

He found “dramatic brain shrinkage and abnormal deposits in and around nerve cells.”

Fig 01- Histopathology of Alzheimer's diseases

(Picture from Neuroscience, Purves, et al)

Brain shrinkage and the abnormal deposit in this day are called amyloid plaques and neurofibrillary tangles.

From the picture, the yellow color are neurofibrillary tangles, and brown dark are amyloid plaques.

Specifically, it is in the neocortex, amygdala, and brainstem

The causes of Alzheimer's Disease is not fully understand yet.

Fig 02- Hot sauce, illustration only

Fig 03- Pomegranate, just for illustration

There are three principle features could be detected in every person who severe with the Alzheimer's disease:

1) Collection of intra-neuronal cytoskeletal filaments or neurofibrillary tangles, also we know as aggregate tau protein in the brain.

- tau protein to maintain microtubules steadiness in axons.

2) extracellular deposit of an abnormal amyloid or amyloid plaques.

3) A diffuse loss of neurons.

- The accumulation of neurofibrillary tangles and amyloid plaques lead to death of neuron cells so that the brain became shrinkage.

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